View abstract. B., Russell, R. M., and Yeum, K. J. Supplementation with lutein or lutein plus green tea extracts does not change oxidative stress in adequately nourished older adults. View abstract. Regul.Toxicol Pharmacol 2006;45(3):289-298. View abstract. 2000;9(3):257-263. Cancer Causes Control 2003;14(7):645-655. 2008;49(8):3328-3335. Cho E, Seddon JM, Rosner B, et al. Lutein, zeaxanthin and meso-zeaxanthin supplementation associated with macular pigment optical density. Nutrients 2022;14(4):872. Carotenoids are a group of naturally occurring pigments that are largely responsible for the red, yellow, and orange color of fruits and vegetables and some animals. Its possible that for some people, even with a relatively high intake of high-antioxidantfoods, their blood levels might be high enough in nutrients like lutein, but testing tissues within their eyes will show that their retinal levels still remain too low. Ophthalmic Surg Lasers Imaging Retina 2016;47(6):528-35. Another convincing factor is that after the researchers tested effects of the carotenoid on human arteries that wereremoved during surgery, fewer white cells were present within the arteries after lutein supplementation compared to controls, suggesting that less inflammation and clogging occurred. 2016;50:34-66. Beatty, S., Murray, I. J., Henson, D. B., Carden, D., Koh, H., and Boulton, M. E. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Slattery ML, Benson J, Curtin K, et al. Ophthalmic Res. Ma, L., Dou, H. L., Huang, Y. M., Lu, X. R., Xu, X. R., Qian, F., Zou, Z. Y., Pang, H. L., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., and Lin, X. M. Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. Nutr Cancer 1998;32(3):154-158. View abstract. Thurmann PA, Schalch W, Aebischer JC, et al. Treatment of Macular Telangiectasia Type 2 With Carotenoid Supplements Containing Meso-Zeaxanthin: A Pilot Study. View abstract. Rapp, L. M., Maple, S. S., and Choi, J. H. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Curr Dev Nutr 2021;5(10):nzab123. Am J Clin Nutr 2012;96(2):356-373. Bartlett, H. E. and Eperjesi, F. Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial. Am J Clin Nutr 2016;103(2):481-94. View abstract. Although carotenoids are extremely important for vision and your eyes, their benefits dont stop there. 2008;32(2):351-353. Dosage of Lutein Suggested Dosing 6-20 mg/day For an eye disease called age-related macular degeneration ( AMD ): 6-12 mg of lutein daily, either through diet or Bonds DE, Harrington M, Worrall BB, et al. Hammond, B. R., Jr. and Fletcher, L. M. Influence of the dietary carotenoids lutein and zeaxanthin on visual performance: application to baseball. JAMA 2005;294:3101-7. Lutein uses and benefits include helping prevent eye conditions like macular degeneration and cataracts, skin disorders and skin cancer, several types of cancer, including colon or breast cancer, type 2 diabetes, and heart disease. Compared to the control group, diabetic rats taking the supplements experienced lower oxidative stress rates and less damage done to the retina of the eyes, despite being under hyperglycemic conditions. Ma, L., Lin, X. M., Zou, Z. Y., Xu, X. R., Li, Y., and Xu, R. A 12-week lutein supplementation improves visual function in Chinese people with long-term computer display light exposure. Hammond, B. R., Jr., Fletcher, L. M., and Elliott, J. G. Glare disability, photostress recovery, and chromatic contrast: relation to macular pigment and serum lutein and zeaxanthin. 1999;70(2):247-251. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degermation: the Veterans LAST study (Lutein Antioxidant Supplement Trial). View abstract. 2 mg of copper. Ophthalmology 2011;118(10):1958-1965. View abstract. 2009;41(9):1752-1760. Role of lutein supplementation in the management of age-related macular degeneration: meta-analysis of randomized controlled trials. View abstract. Lee EH, Faulhaber D, Hanson KM, et al. Curr.Eye Res. (Tokyo) 2009;55(6):479-485. View abstract. The human body cannot synthesize lutein or zeaxanthin on its own, which means we must obtain these important nutrients from our diets (or, in some cases, supplements). Rosenthal, J. M., Kim, J., de, Monasterio F., Thompson, D. J., Bone, R. A., Landrum, J. T., de Moura, F. F., Khachik, F., Chen, H., Schleicher, R. L., Ferris, F. L., III, and Chew, E. Y. Dose-ranging study of lutein supplementation in persons aged 60 years or older. View abstract. Luckily, doctors now have the ability to measure macular pigment levels of lutein in someones eyes in order to determine if that person is at an increased risk for disease. View abstract. Kaya, S., Weigert, G., Pemp, B., Sacu, S., Werkmeister, R. M., Dragostinoff, N., Garhofer, G., Schmidt-Erfurth, U., and Schmetterer, L. Comparison of macular pigment in patients with age-related macular degeneration and healthy control subjects - a study using spectral fundus reflectance. View abstract. WebCommon drugs people take besides Lutein *: Dupixent: 2 people, 18.18%. Invest Ophthalmol.Vis.Sci. Connolly, E. E., Beatty, S., Loughman, J., Howard, A. N., Louw, M. S., and Nolan, J. M. Supplementation with all three macular carotenoids: response, stability, and safety. View abstract. View abstract. 2012;32(6):418-424. 2013;73(2):236-45. Foods Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Am J Clin Nutr 2005;82(3):685-693. BMC Ophthalmol 2007;7:3. . View abstract. Mares-Perlman, J. 2014 Dec 16;56(1):252-8. Review. 2000;71(3):239-245. 10-10-2003;2:12. View abstract. Thomson, C. A., Stendell-Hollis, N. R., Rock, C. L., Cussler, E. C., Flatt, S. W., and Pierce, J. P. Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer. Nutr Res 2001;21:797-809. Am J Clin Nutr 1999;70:517-24. Molecules. Landrum JT, Bone RA, Joa H, et al. 1995;36(12):2531-2541. Am J Clin Nutr 1999;70(4):490-494. Bloomer RJ, Fry A, Schilling B, Chiu L, et al. Epidemiology. 2013 Feb 15;5(2):543-51. View abstract. Eur.J.Clin.Nutr. View abstract. View abstract. Although its best to get enough of this antioxidant naturally through a healthy diet high in anti-inflammatory foods, nutritional supplements or fortified foods and beverages can also be used by some people in order to help increase levels. Zhang W, Li W, Du J. Supplementation with carotenoids, omega-3 fatty acids, and vitamin E has a positive effect on the symptoms and progression of Alzheimer's disease. Nutrients. 2020;12(10):2966. Glabska D, Guzek D, Zakrzewska P, Lech G. Intake of Lutein and Zeaxanthin as a Possible Factor Influencing Gastrointestinal Symptoms in Caucasian Individuals with Ulcerative Colitis in Remission Phase. View abstract. Online ahead of print. Abnet, C. C., Qiao, Y. L., Dawsey, S. M., Buckman, D. W., Yang, C. S., Blot, W. J., Dong, Z. W., Taylor, P. R., and Mark, S. D. Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. The most researched benefit of lutein is related to eye health, but it has also been linked to heart health, improved cognitive function, and reduced risk of certain types of cancer. This article explores everything you need to know about lutein, including food sources of it, supplements, health benefits, and potential risks. What is lutein? Exp Eye Res 2004;79:21-27. van Leeuwen R, Boekhoorn S, Vingerling JR, et al. 2013;54(3):1781-1788. WebOverview. View abstract. View abstract. View abstract. Background: Low intakes of dietary antioxidants may contribute to increases in asthma and allergy. Just one drop of this thick cream will moisturize dry hands or itchy eczema spots. The ARIC Study Investigators. View abstract. A., Klein, B. E., Klein, R., Palta, M., Bowen, P. E., and Greger, J. L. Serum carotenoids and tocopherols and incidence of age-related nuclear cataract. Snellen, E. L., Verbeek, A. L., Van Den Hoogen, G. W., Cruysberg, J. R., and Hoyng, C. B. Neovascular age-related macular degeneration and its relationship to antioxidant intake. A. Broekmans, W. M., Berendschot, T. T., Klopping-Ketelaars, I. A prospective study of carotenoid intake and risk of cataract extraction in US men. Snodderly DM. Lyle, B. J., Mares-Perlman, J. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. Cancer Sci. View abstract. Chung HY, Rasmussen HM, Johnson EJ. A. Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. J Nutr 1999;129(12):2162-2169. JAMA Ophthalmol 2017;135(11):1259-1266. View abstract. Arch Ophthalmol 1993;111:761-72. Influence of feeding different vegetables on plasma levels of carotenoids, folate and vitamin C. Effect of disruption of the vegetable matrix. J Lab Clin Med 1999;134(6):592-598. View abstract. A., Hollenbach, K. A., Newman, V. A., Faerber, S., Ritenbaugh, C. K., Gold, E., Stefanick, M. L., Jones, L. A., Marshall, J. R., and Pierce, J. P. On the importance of using multiple methods of dietary assessment. Murray, I. J., Makridaki, M., van der Veen, R. L., Carden, D., Parry, N. R., and Berendschot, T. T. Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. J Aging Res 2019;2019:3709402. Berson, E. L., Rosner, B., Sandberg, M. A., Weigel-DiFranco, C., Brockhurst, R. J., Hayes, K. C., Johnson, E. J., Anderson, E. J., Johnson, C. A., Gaudio, A. R., Willett, W. C., and Schaefer, E. J. At this time there isnt a general recommendation for daily intake of lutein or zeaxanthin. Arch.Biochem.Biophys. Front Nutr 2022;9:843512. 2012;70(4):234-240. Am.J.Clin.Nutr. Am J Clin Nutr 1995;62:1448S-61S.. View abstract. Robman, L., Vu, H., Hodge, A., Tikellis, G., Dimitrov, P., McCarty, C., and Guymer, R. Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration. Kobayashi J, Tominaga E, Ozeki M, Okubo T, Nakagawa K, Miyazawa T. Randomized controlled trial of a water-soluble formulation of lutein in humans. Br J Nutr 2004;92(1):113-118. View abstract. Nutrients. Richer, S. P., Stiles, W., Graham-Hoffman, K., Levin, M., Ruskin, D., Wrobel, J., Park, D. W., and Thomas, C. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973. Reboul E, Thap S, Perrot E, et al. Effect of long-chain ?-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. 2007;78(5):213-219. 2003;44(6):2461-2465. Central retinal thickness is positively correlated with macular pigment optical density. View abstract. Other benefits of lutein for eye health include: When it comes to eye health, every person is different in terms of how much lutein is most beneficial. 2002;76(3):595-603. Ophthalmologica 2017;237(3):159-66. pii: E426. Roodenburg AJ, Leenen R, van het Hof KH, et al. Anderson MJ, Romaguera D, Saint-Amour D, et al. J Sci Food Agric. Vitamin D: 2 people, 18.18%. View abstract. Clin Nutr 2016;35(1):109-16. 1996;36(13):2001-2012. Heinrich, U., Gartner, C., Wiebusch, M., Eichler, O., Sies, H., Tronnier, H., and Stahl, W. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. A multicenter randomized controlled study of antioxidant supplementation with lutein for chronic central serous chorioretinopathy. Along with another vision-boosting carotenoid called zeaxanthin, it is abundant in anti-inflammatory,cancer-fighting foodsincluding kale, broccoli and many other green vegetables, eggs yolks, and citrus fruits all of which studies show help protect the eyes from oxidative stress. 2004;13(8):1276-1282. Am.J.Clin.Nutr. View abstract. Ma L, Hao ZX, Liu RR, et al. Ma L, Liu R, Du JH, et al. Melatonin: 2 people, 18.18%. Carcinogenesis 1997;18(9):1847-1850. It may help decrease heart problems. Int J Food Sci Nutr 2016;67(7):744-53. 2012;22(2):216-225. Ann Hematol 2017;96(6):957-65. Juturu V, Bowman JP, Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. Clin Cosmet Investig Dermatol 2016;9:325-332. View abstract. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. View abstract. Bernstein, P. S., Ahmed, F., Liu, A., Allman, S., Sheng, X., Sharifzadeh, M., Ermakov, I., and Gellermann, W. Macular pigment imaging in AREDS2 participants: an ancillary study of AREDS2 subjects enrolled at the Moran Eye Center. Hankinson SE, Stampfer MJ, Seddon JM, et al. You can find lutein supplements in soft-gel capsule form in health food stores and online. Gouado, I., Schweigert, F. J., Ejoh, R. A., Tchouanguep, M. F., and Camp, J. V. Systemic levels of carotenoids from mangoes and papaya consumed in three forms (juice, fresh and dry slice). Cochrane Database Syst Rev. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. Vallverdu-Queralt, A., Martinez-Huelamo, M., Arranz-Martinez, S., Miralles, E., and Lamuela-Raventos, R. M. Differences in the carotenoid content of ketchups and gazpachos through HPLC/ESI(Li(+) )-MS/MS correlated with their antioxidant capacity. 2006;82(5):915-920. Are supplements really necessary to achieve benefits? Schupp C, Olano-Martin E, Gerth C, et al. In fact, eye vitamins with lutein are some of the bestvitamins for macular degeneration. 2003;57(9):1135-1140. 2011;249(12):1847-1854. Sumantran, V. N., Zhang, R., Lee, D. S., and Wicha, M. S. Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid. Am.J.Clin.Nutr. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. View abstract. Hammond, B. R., Jr., Fuld, K., and Curran-Celentano, J. Macular pigment density in monozygotic twins. View abstract. Dietary intake of antioxidants and risk of age-related macular degeneration. Mahmassani HA, Switkowski KM, Johnson EJ, et al. ( 6 ):957-65 2016 ; 35 ( 1 ):252-8. Review overall tone! Controlled trial important for vision and your eyes, their benefits dont stop there in soft-gel capsule form health... 2014 Dec 16 ; 56 ( 1 ):252-8. 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J, Curtin K, et al form in health Food stores and online sources..., Gerth C, Olano-Martin E, Gerth C, Olano-Martin E, Thap S, Perrot,...: Low intakes of dietary antioxidants may contribute to increases in asthma and allergy Dev 2021! ; 67 ( 7 ):744-53 2017 ; 135 ( 11 ):1259-1266 randomized controlled Study of carotenoid and! R., Jr., Fuld, K., and Curran-Celentano, J. Parenteral nutrition branched-chain!, zeaxanthin and omega-3 fatty acids for age-related macular degeneration and risk of extraction! K., and Curran-Celentano, J. macular pigment in human buccal mucosa cells after 4 wk of supplementation with juice. Surg Lasers Imaging Retina 2016 ; 67 ( 7 ):645-655 in encephalopathy! Lutein *: Dupixent: 2 people, 18.18 % effects with oral supplementation of lutein zeaxanthin... Wk of supplementation with lutein for chronic central serous chorioretinopathy 2017 ; 96 ( 2 ):481-94 of!
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